Differential enhancement of interferon-γ-induced MHC class II expression of HEp-2 cells by 1,25-dihydroxyvitamin D3
- 1 September 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 123 (3) , 333-338
- https://doi.org/10.1111/j.1365-2133.1990.tb06293.x
Abstract
Interferon‐γ (IFN‐γ) induces the expression of MHC class II antigens on non‐lymphoid cells. In this study we investigated the effect of 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3), the most active metabolite of vitamin D3, on the IFN‐γ‐induced expression of MHCclass II antigens on HEp‐2 cells. We found that 1,25(OH)2D3 enhanced the IFN‐γ‐induced expression of HLA‐DR on these cells. Differential effects on the MHC class II antigens HLA‐DR, ‐DQ and ‐DP were also observed.This publication has 15 references indexed in Scilit:
- The effect of 1,25-dihydroxyvitamin D3 on in vitro immunoglobulin production in human B cells.The Journal of Immunology, 1986
- Interferon-gamma-induced IA expression in WEHI-3 cells is enhanced by the presence of 1,25-dihydroxyvitamin D3.The Journal of Immunology, 1986
- Possible Functions of 1α,25-Dihydroxyvitamin D3, an Active Form of Vitamin D3, in the Differentiation and Development of SkinJournal of Investigative Dermatology, 1985
- Structure, Function, and Genetics of Human Class II MoleculesPublished by Elsevier ,1985
- Recombinant Gamma Interferon Differentially Regulates Class II Antigen Expression and Biosynthesis on Cultured Normal Human KeratinocytesJournal of Interferon Research, 1985
- Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol).Journal of Clinical Investigation, 1984
- Recombinant Gamma Interferon Induces HLA-DR Expression on Cultured Human KeratinocytesJournal of Investigative Dermatology, 1984
- Recombinant interferon-gamma increases HLA-DR synthesis and expression.The Journal of Immunology, 1983
- Differentiation of mouse myeloid leukemia cells induced by 1 alpha,25-dihydroxyvitamin D3.Proceedings of the National Academy of Sciences, 1981
- Ia Antigens in Mouse Skin Are Predominantly Expressed on Langerhans CellsThe Journal of Immunology, 1979