Cd-induced proteinuria was reversible in some workers. Three of 5 workers who showed positive proteinuria in 1965 revealed negative results in recent years after the cessation of Cd exposure or after the improvement of the working environment and personal hygiene. However, 2 of the 3 workers with negative proteinuria still showed slightly increased levels of B2MG [.beta.-2-microglobulin?] and the 2 workers with persistent proteinuria showed a moderate increase of B2MG. This situation may depend on the history of Cd exposure. The association between Cd in urine and proteinuria after the cessation of exposure is not yet clear. In some workers, in spite of a decreased excretion of protein in urine, there was no sharp decrease of Cd in urine. Anemia and other biochemical changes also seem to be reversible if the exposure to Cd is decreased. When Cd concentration in the working environment is decreased to about 20 .mu.g/m3, the general health status of workers improves remarkably. Of course, the improvement of the working environment also elevated the level of awareness of the workers to the dangers of indiscriminatory exposure to Cd.