A rapid and efficient synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose and ‐D‐galactopyranose
- 1 July 1990
- journal article
- research article
- Published by Wiley in Journal of Labelled Compounds and Radiopharmaceuticals
- Vol. 28 (7) , 847-854
- https://doi.org/10.1002/jlcr.2580280715
Abstract
Rapid and efficient syntheses of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐mannopyranose (1) and ‐D‐galactopyranose (2), respectively, starting from [18F]fluoride and ethyl bromoacetate are described. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total times required for synthesis of (1) and (2) are ca. 80 min. The radiochemical yield and purity of (1) are an 18% and ≥98%, respectively. Compound (2) is also synthesized with the same radiochemical yield and purity.This publication has 5 references indexed in Scilit:
- An efficient, one‐pot synthesis of 2‐deoxy‐2‐[18F]fluoroacetamido‐D‐glucopyranose (N‐[18F]fluoroacetyl‐D‐glucosamine), potential diagnostic imaging agentJournal of Labelled Compounds and Radiopharmaceuticals, 1989
- [18F]fluoride production with a circulating [18O]water targetInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1987
- Haloacetamido analogs of 2-amino-2-deoxy-D-mannose. Syntheses and effects on tumor-bearing miceJournal of Medicinal Chemistry, 1981
- Fluorinated CarbohydratesPublished by Elsevier ,1981
- Haloacetamido analogs of 2-amino-2-deoxy-D-glucose and 2-amino-2-deoxy-D-galactose. Syntheses and effects on the Friend murine erythroleukemiaJournal of Medicinal Chemistry, 1978