CIMETIDINE PREVENTS REDUCTION IN GASTRIC MUCOSAL BLOOD-FLOW DURING SHOCK

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 84  (1) , 113-119
Abstract
Cimetidine''s possible role in regulating gastric mucosal blood flow was evaluated in the anesthetized, stressed miniature swine. Stress consisted of hemorrhagic shock to a mean arterial pressure of 50 mm Hg. Twenty-one animals were divided into 3 experimental groups: untreated controls, preshock Cimetidine treatment group and postshock Cimetidine treatment group. Gastric mucosal blood flows were determined (microsphere method) during a stabilization period and after 90 min of shock. Central hemodynamic indices were monitored throughout each experiment. In the fundus, mucosal blood flow decreased 59% in the controls, 11% in the preshock and 28% in the postshock Cimetidine groups. Antral mucosal blood flow decreased 57% in controls, 19% in the preshock and 33% in the postshock Cimetidine groups. In the corpal mucosa, blood flow decreased 53% in controls, 11% in the preshock group and 41% in the postshock Cimetidine group. Cimetidine administration, both before and after shock, conferred significant protection on mucosal blood flow changes related to shock. Preshock drug administration had a significantly greater protective effect than postshock treatment on blood flow in the corpal mucosa.