Betahistine in peripheral vertigo

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Abstract
Meniere''s disease is an uncommon condition. Far more common is the condition variously referred to as atypical Meniere or peripheral vertigo. A study of patients with known peripheral vertigo was undertaken by using the cerebral vasodilator betahistine dihydrochloride (Serc). Betahistine dihydrochloride is an histamine analog with a proven ability to improve the microcirculation of the inner ear, as shown in animal experiments (Kubicek et Anderson, 1967; Martinez, 1972), and confirmed in double-blind, placebo-controlled clinical trials (Frew et Menon, 1976; Wilmot et Menon, 1976). The possible efficacy of Sercin patients with episodic vertigo of the peripheral type, according to the criteria of Kane et Strong (1957), but without established cause was investigated. The study was carried out in the Ear, Nose and Throat Department of the Manchester Royal Infirmary [UK] between Oct. 1974-June 1976.

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