Synthesis and biological activity of 13-epi-avermectins: potent anthelmintic agents with an increased margin of safety
- 1 October 1992
- journal article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 35 (21) , 3873-3878
- https://doi.org/10.1021/jm00099a014
Abstract
Chemical conversion of the potent anthelmintic natural products avermectin B1 (1) and avermectin B2 (3) to the corresponding 13-epi analogs (15 and 9) is described. The novel analogs retain the full potency of the natural products but are substantially safer.Keywords
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