Correlation of Cellular Aggregation of Transformed Cells with Their Growth in Soft Agar and Tumorigenic Potential
- 1 September 1977
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 155 (4) , 487-494
- https://doi.org/10.3181/00379727-155-39836
Abstract
Formation of cellular aggregates by rat, mouse, hamster and human transformed cells was compared to aggregate formation by untransformed control cells. Viability and proliferation of cells in the aggregate form correlated well with tumorigenic potential regardless of the method of transformation (spontaneous, chemical or virus-induced). This assay has the potential for a fast and accurate means of evaluating in vitro transformation.This publication has 2 references indexed in Scilit:
- Formation of Larger Cell Aggregates by Transformed Cells: An In Vitro Index of Cell Transformation2JNCI Journal of the National Cancer Institute, 1976
- Aggregation of Tumour CellsNature, 1966