Effect of an Analogue of DDT on Experimental Murine Typhus.

Publisher Website
Google Scholar
Abstract
Mice of the dba strain infected with murine typhus were successfully treated with the nitro analogue of DDT, 1,1,1-trichloro-2,2-bis(p-nitrophenyl) ethane. The compound was incorporated in ground Rockland chow at a level of 0.5% and fed for 7 days beginning at the time of infection. The degree of survival on the 7th day was equal to that obtained when 4 times the quantity of p-aminobenzoic acid (PABA) was given under the same conditions. When the drug was withdrawn, more PABA-treated mice succumbed, indicating that the nitro analogue is a better rickettsiacidal agent. Preliminary tests indicate that the toxicity of the compound is of a low order, since 20 mice showed no untoward symptoms during a week''s observation following a single oral dose of 5 g./kg.

This publication has 1 reference indexed in Scilit: