BLOCKADE BY BURIMAMIDE OF THE RESTORATIVE EFFECT OF HISTAMINE IN TETRODOTOXIN‐TREATED HEART PREPARATIONS
Open Access
- 1 June 1976
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 57 (2) , 247-249
- https://doi.org/10.1111/j.1476-5381.1976.tb07474.x
Abstract
1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2–4 × 10−5 m), excitability was restored by histamine (6 × 10−6 M to 10−5 m). 2 This effect was antagonized by EDTA (2 × 10−6 m), D600 compound (0.5 μg/ml) and the H2-receptor antagonist, burimamide (2 × 10−4 m).Keywords
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