The In Vivo Metabolism of Tertiary Butanol by Adult Rats

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Abstract
The metabolism of tertiary butanol has been considered to be limited to direct conjugation of the hydroxyl group. Therefore, the alcohol has been used to differentiate between the direct effects of ethanol and those caused by metabolism or metabolic products of ethanol. The in vitro oxidation of tertiary butanol has been reported, and in this report we describe the in vivo oxidation of tertiary butanol. Radiolabeled and stable isotope-labeled acetone was recovered from animals treated with corresponding labeled t-butanol. 14CO2 was also recovered from animals treated with [14C]t-butanol.