Endothelin Antagonism on Aldosterone-Induced Oxidative Stress and Vascular Remodeling

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Abstract
Endothelin A (ET A ) receptor blockade has prevented vascular remodeling in aldosterone and salt-induced hypertension. To evaluate effects of the ET A receptor antagonist, BMS 182874, compared with the aldosterone antagonist, spironolactone, on vascular remodeling in aldosterone-infused rats not exposed to a high salt diet, Sprague-Dawley rats were infused subcutaneously with aldosterone (0.75 μg/h) and treated with BMS 182874 (40 mg · kg −1 · d −1 ), spironolactone, or hydralazine (both 25 mg · kg −1 · d −1 ) while receiving a normal salt diet for 6 weeks. Aldosterone increased systolic BP ( P P P P A receptors. Endothelin blockade may exert beneficial effects on vascular remodeling, fibrosis, oxidative stress, and adhesion molecule expression in aldosterone-induced hypertension.