Effect of BAL on Survival of Rats after Lethal Doses of Polonium.
- 1 February 1952
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 79 (2) , 210-212
- https://doi.org/10.3181/00379727-79-19324
Abstract
A group of 18 adult Wistar strain albino rats received 36 uc./kg. of polonium chloride. Nine rats were given BAL intramusc. 004 ml./dose, 3 doses a day, for a total treatment time of 3 days. The median survival time of the BAL rats was 89 days as compared with a median survival time of 22 days for the untreated group. Blood studies show well sustained cell and platelet levels for the BAL group as contrasted to the precipitous drop in cells and platelets for the control rats. The 2 aforesaid effects are interpreted as brought about by the action of BAL in increasing the excretion of polonium and in diverting polonium from the radiation-sensitive spleen and bone marrow into radiation-insensitive muscle.Keywords
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