Studies on High Density Lipoproteins in Fish Eye Disease

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Abstract
Serum high density lipoproteins (HDL) were isolated by preparative ultracentrifugation from 2 patients with fish disease (FED). Compared to HDL from control subjects the HDL particles of FED were characterized by their abnormally small size and a relative enrichment with polar lipids. No qualitative abnormalities of the HDL apolipoproteins were revealed upon polyacrylamide disc gel electrophoresis or isoelectric focusing. The plasma pool of apolipoprotein A was reduced by 90%.