Perfusion and diffusion MR imaging

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Abstract
Diffusion-weighted images of the rat brain were obtained using the pulsed-gradient spinecho method. An attempt was made to extract perfusion-related parameters from signal intensity data taken from the caudate-putamen region of the images, by using a nonlinear least-squares calculation to fit the Le Bihan biexponential expression (Le Bihan et al., Radiology, 168, 497 (1988)) to the data. The perfusion-related parameters could not be obtained with sufficient accuracy to be useful, although the perfusion-weighted images appear to contain meaningful qualitative information. An analysis of the perfusion model is presented and shows why the Le Bihan pseudo-diffusion coefficient is particularly difficult to measure with reasonable accuracy. © 1992 Academic Press, Inc.
Funding Information
  • Wolfson Foundation
  • Camilla Samuel Trust
  • Medical Research Council
  • Rank Foundation
  • Wellcome Trust
  • Imperial Cancer Research Fund