EVIDENCE OF IMMUNE RESPONSE TO ORTHOTOPIC TOOTH ALLOGRAFTS IN SYRIAN HAMSTERS

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Abstract
SUMMARY The survival of tooth isografts and allografts was studied in sensitized and normal hamsters. The host reaction to orthotopic tooth allografts was similar to isografts and replants in unsensitized recipients. In contrast, prior sensitization of the recipient by skin grafting resulted more frequently in loss of the tooth allografts and in more intense and characteristic histological changes in their graft beds. Lymphocytes were especially prominent in these transplants. The peak inflammatory response was reached 14-21 days after transplantation. Similarly, skin graft recipients could be sensitized by tooth allografts. Thus, the normal median survival time (MST) of skin (11.3 days) in the strain combination employed was reduced to 7.8 days following exposure to an orthotopic tooth allograft. These observations indicate that teeth as used in clinical transplantation are antigenic.

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