VASOVAGAL HYPOTENSION AND VASOPRESSIN RELEASE

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Abstract
Mild vasovagal hypotension occurred in 2 normal male volunteers during insertion of indwelling venous cannulae. Despite a rapid i.v. fluid load (3.6-4.6 l in 90 min), both subjects passed little urine for 100 min. When the experiment was repeated without vasovagal hypotension, a rapid large diuresis followed the fluid load. Prolonged oliguria after vasovagal hypotension was the result of vasopressin release. This was demonstrated by measuring vasopressin the blood and urine and by observing the renal response to a water load. The observation in man that a mild transient hypotensive episode may reduce urine flow for 100 min has clinical significance.