Synthesis of GDP 4,6-Dideoxy-β-L-xylohexopyranose (GDP-4-deoxy-β-L-fucose)

Abstract
GDP 4,6-dideoxy-ß-L-xylohexopyranose (GDP-4-deoxyfucose, 4) was synthesized from dibenzyl (2,3-di-O-benzoyl-4, 6-dideoxy-4-iodo-ß-L-glucopyranosyl) phosphate (1) by coupling with guanosine monophosphomorpholidate either directly after hydrogenation or after subsequent deesterification.

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