Selective killing of normal or neoplastic B cells by antibodies coupled to the A chain of ricin.
Open Access
- 1 September 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (9) , 5419-5423
- https://doi.org/10.1073/pnas.77.9.5419
Abstract
Highly specific antibodies (affinity-purified or hybridoma) directed against cell surface Ig on normal or neoplastic murine B lymphocytes were covalently coupled to the A chain of the plant toxin ricin. Such conjugates containing antibodies specific for IgM, for either of the 2 allotypes of IgD, or for the idiotype of the B cell tumor BCL1 rapidly bound in vitro to cells expressing the corresponding surface antigen and inhibited protein synthesis in such cells. A chain-coupled anti-idiotype antibody may be useful as a tumor-specific cytotoxic agent.This publication has 22 references indexed in Scilit:
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