Antibody synthesis in kidney, spleen and lymph nodes in acute and healed focal pyelonephritis.

  • 1 December 1971
    • journal article
    • Vol. 52  (6) , 678-83
Abstract
Segmental circumscribed pyelonephritis in rabbits was associated with a significant increase in the incorporation of 14C amino acids into IgG by the infected kidneys and spleen. Specific anti-Esch. coli antibody in the IgG class was synthesized by 8 of 10 kidneys, 5 of 10 spleens, 1 of 6 proximal lymph nodes, 1 of 3 popliteal lymph nodes and by none of the “buffy coat” cells (circulating lymphocytes). Although viable organisms were not present, non-viable antigen persisted for up to 6 months after infection. Persistent circulating antibody may arise from local antibody which is stimulated by the persistence of non-viable antigen at site of infection.