Diabetic Coma with Acute Inflammation of Islets of Langerhans

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Abstract
IN 1927, Warren1 stated that the pathological changes in the pancreas in diabetes during childhood may contribute more to the understanding of the disease than those observed when the disease occurs in later life. In particular, he referred to patients with fulminating diabetes who die in diabetic coma shortly after the onset of the disease. Cellular infiltration of the islets of Langerhans was mentioned as a very rare occurrence by early investigators of diabetes2-4 but it was not clearly documented until 1928, when Stansfield and Warren5 reported two cases of leukocytic infiltration of the islets in children aged 6 yr and 11 yr, who died in diabetic coma. Is this lesion as rare as the paucity of reports indicates, or is it a more common entity which remains unrecognized? Report of a Case A 9-mo-old boy was brought to Kenmore Mercy Hospital because of emesis two or

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