Photodynamic Efficiency of Protoporphyrin IX: Comparison of Endogenous Protoporphyrin IX Induced by 5‐Aminolevulinic Acid and Exogenous Porphyrin IX

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Abstract
Abstract— Photodynamic efficiency of protoporphyrin IX (PP) accumulated in HeLa cells by the incubation of PP with HeLa cells was compared with that of accumulated PP formed from 5‐aminolevulinic acid (ALA) as a precursor. The ALA‐induced PP was photodynamically more efficient than exogenous PP. The difference is caused by monomelic PP concentration and PP localization site in HeLa cells. Exogenous PP was accumulated mainly in plasma membrane, and the membrane was strongly damaged by irradiation. The ALA‐induced PP was selectively accumulated in mitochondria and inactivated the mitochondrial function by irradiation.