Allele-specific gene probing supports the DQ molecule as a determinant of inherited susceptibility to Type 1 (insulin-dependent) diabetes mellitus
- 1 February 1991
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 34 (2) , 109-113
- https://doi.org/10.1007/bf00500381
Abstract
Trans-racial analysis of disease associations has improved mapping of MHC-linked susceptibility to Type 1 (insulin-dependent) diabetes mellitus. In this study the contributions of the MHC class II DQA1 and DQB1 genes were investigated. Sequence-specific oligonucleotide gene probing in Type 1 diabetic and control subjects of North Indian origin supported the DQw1.18 allele of the DQB1 gene as a determinant of inherited protection against Type 1 diabetes (RR=0.12, pcpcpc<0.01). Trans-racial comparison of these disease associations indicates that DQ alleles may directly determine an element of inherited susceptibility to Type 1 diabetes.Keywords
This publication has 24 references indexed in Scilit:
- Analysis of HLA-DQ Genotypes and Susceptibility in Insulin-Dependent Diabetes MellitusNew England Journal of Medicine, 1990
- The A3 allele of the HLA-DQA1 locus is associated with susceptibility to type 1 diabetes in Japanese.Proceedings of the National Academy of Sciences, 1990
- Nomenclature for factors of the HLA system, 1989Tissue Antigens, 1990
- Trans-racial studies implicate HLA-DQ as a component of genetic susceptibility to Type 1 (insulin-dependent) diabetesDiabetologia, 1988
- Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.Proceedings of the National Academy of Sciences, 1988
- A hypothetical model of the foreign antigen binding site of Class II histocompatibility moleculesNature, 1988
- Genetics and Polymorphism: Class II AntigensBritish Medical Bulletin, 1987
- The Southall Diabetes Survey: prevalence of known diabetes in Asians and Europeans.BMJ, 1985
- HLA DR ANTIGENS AND SUSCEPTIBILITY TO INSULIN-DEPENDENT DIABETES-MELLITUS1984
- HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individualsNature, 1983