D2 Dopamine Receptor Occupancy: A Crossover Comparison of Risperidone With Clozapine Therapy in Schizophrenic Patients

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Abstract
The atypical antipsychotic agents, clozapine and risperidone, have a similar pharmacological profile of D2dopamine receptor affinity, α2, and serotonin2antagonism.1Despite this similarity, the clinical profile of these 2 drugs are quite different. For instance, risperidone produces dose-dependent extrapyramidal side effects, whereas clozapine does not.2Moreover, there may be differences in the antipsychotic efficacy of these 2 drugs n treatment-resistant patients. One possibility for this difference in clinical profile is that these drugs produce different levels of D2receptor occupancy. Previous estimates of D2receptor occupancy of these atypical agents have examined different individuals and do not account for interindividual variation.3, 4We are, therefore, conducting a double-blind, randomized, crossover sodium iodide I123-benzamide—single photon emission computed tomographic study with schizophrenic patients treated with fixed doses of clozapine and risperidone to investigate the degree of D2receptor occupancy by these drugs. To date, we

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