THE PROBABILITY OF DETECTING THE ORIGIN OF NONDISJUNCTION OF AUTOSOMAL TRISOMIES
- 1 May 1989
- journal article
- research article
- Vol. 44 (5) , 639-645
Abstract
For studying the biology of autosomal trisomies it is necessary to establish the parental origin and meiotic stage of nondisjunction by using genetic markers. Theoretical formulas are obtained for calculating the probability of establishing (1) parental origin and meiotic stage of nondisjunction by using a centrometric marker, (2) parental origin of nondisjunction by using a noncentromeric marker, and (3) meiotic stage, given parental origin of nondisjunction. These theoretical calculations demonstrate that parental origin of nondisjunction can be identified with virtual certainty by utilizing multiple genetic markers along a chromosome arm. Centromeric markers are by themselves inefficient for determining meiotic stage of the error, but the efficiency can be considerably increased if parental origin is known with certainty. Even then, multiple centromeric markers may be necessary.This publication has 17 references indexed in Scilit:
- The use of DNA probes to establish parental origin in Down syndromeHuman Genetics, 1988
- Cytogenetic and molecular studies of trisomy 13.Journal of Medical Genetics, 1987
- Methods for studying recombination on chromosomes that undergo nondisjunctionGenomics, 1987
- Evidence for Reduced Recombination on the Nondisjoined Chromosomes 21 in Down SyndromeScience, 1987
- Variable Number of Tandem Repeat (VNTR) Markers for Human Gene MappingScience, 1987
- TRISOMY IN MANAnnual Review of Genetics, 1984
- Parental origin of autosomal trisomiesAnnals of Human Genetics, 1984
- Use of a chromosome 21 cloned DNA probe for the analysis of non-disjunction in Down syndromeHuman Genetics, 1984
- Localization of transcripts produced in vivo and in vitro on phage SP82 genomeGene, 1977
- Origin of Human Trisomics and PolyploidsHuman Heredity, 1977