Suicide Transport: Destruction of Neurons by Retrograde Transport of Ricin, Abrin, and Modeccin
- 21 May 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4548) , 889-890
- https://doi.org/10.1126/science.6177039
Abstract
Certain toxic lectins, including ricin, are retrogradely transported along neuronal processes to the cell body where they inactivate ribosomes, resulting in neuronal death. This process of "suicide transport" suggests a powerful new experimental strategy for solving neurobiological problems.This publication has 13 references indexed in Scilit:
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