Immunoelectrophoretic Studies of Fibrinogen, Plasmin and Lytic Products of Fibrinogen and Fibrin

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Abstract
Fibrinogen, plasmin and the lytic products of fibrinogen and fibrin were investigated immunoelectrophoretically employing corresponding antisera produced in rabbits. The fibrinogen was shown to have a changed mobility according to the degree of dilution. The plasmin could not be freed of plasmino-gen. The plasmin-plasminogen precipitate formed with anti-plasmino-gen was located in the [beta]-globulin region. The lytic products of long-term fibrinogenolysis consisted of at least 2 antigenic factors which were related to fibrinogen. The lytic products of fibrinolysis contained two similar factors as well as an additional one. By employing anti-plasminogen to decrease the plasminogen content in the fibrinogen preparation a changed course of the fibrinogenolysis was obtained. This indicates the importance of the quantity of plasmin to the reaction.