RENAL TUBULAR EFFECTS OF SODIUM-FLUORIDE

Publisher Website
Google Scholar
Abstract
[Methoxyflurane undergoes extensive hepatic metabolism to oxalate and inorganic fluoride and patients anesthetized with methoxyflurane may develop a vasopressin-resistant polyuric renal failure.] Administration of NaF results in vasopressin-resistant polyuric renal failure resembling nephrogenic diabetes insipidus. The renal tubular site of action of F is not clear. Fischer 344 rats received acute i.v. infusions of NaF (0.3, 1.47 and 2.20 .mu.mol/min per kg body wt) for 2.5 h, which resulted in dissipation of the renal medullary tissue osmotic gradient and a sustained, dose-related increase in fractional Na excretion and urine flow. Free water reabsorption and excretion were decreased by F, but the decrease in free water excretion occurred only when the F-induced polyuria preceded the onset of the water diuresis. Slices of renal medulla from F-treated rats had lower cAMP concentrations than did slices from the control rats, and the responsiveness of the medullary tissue to vasopressin was markedly reduced. F- dissipates the concentration gradient in the renal medulla largely by inhibiting NaCl reabsorption in the ascending limb of Henle''s loop and inhibits antidiuretic hormone-mediated water reabsorption across the collecting duct.

This publication has 3 references indexed in Scilit: