Tritium nuclear magnetic resonance spectroscopy of [Pyrrolidine-3H]bepridil
- 1 January 1986
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 2
- No. 4,p. 585-591
- https://doi.org/10.1039/p29860000585
Abstract
Bepridil [N-benzyl-3-isobutoxy-N-phenyl-2-(pyrrolidin-1-yl)propylamine] tritiated in the pyrrolidine ring by reduction of the 2,5-dihydropyrrol-1-yl analogue with tritium shows a complicated 1H-decoupled 3H n.m.r. spectrum. With the aid of isotopic fractionation by h.p.l.c. this spectrum could be interpreted as a sum of the spectra of various mono-, di-, and tri-tritiated diastereoisomers. In the case of the (+)-(R)-isomer of bepridil the optical purity could be determined by 3H n.m.r. in the presence of Pirkle's alcohol.Keywords
This publication has 0 references indexed in Scilit: