Monoallelic expression of IGF2 at the human fetal/maternal boundary
- 1 June 1995
- journal article
- research article
- Published by Wiley in Molecular Reproduction and Development
- Vol. 41 (2) , 177-183
- https://doi.org/10.1002/mrd.1080410208
Abstract
IGF2 is expressed in both placental and decidual tissues, enabling an analysis of the parental imprinting over the fetomaternal boundary. Evidence is provided that IGF2 is monoallelically expressed in both placenta and pregnant, as well as nonpregnant, endometrium. These observations suggest that the maternally derived IGF2 allele is inactivated during germline transmission. Comparison of promoter usage in decidua and placental samples shows that the P3 promoter appears to regulated independently of the others. These observations are discussed with respect to current models of IGF2 imprinting and the hypothesized conflict of parental reproductive interests which bears on the phenomenon of parental imprinting.Keywords
This publication has 30 references indexed in Scilit:
- Parental imprinting of autosomal mammalian genesCurrent Opinion in Genetics & Development, 1994
- The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humansNature Genetics, 1993
- Parental genomic imprinting of the human IGF2 geneNature Genetics, 1993
- IGF2 is parentally imprinted during human embryogenesis and in the Beckwith–Wiedemann syndromeNature Genetics, 1993
- Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumourNature, 1993
- Genetic analysis of genomic imprinting: An Imprintor-1 gene controls inactivation of the paternal copy of the mouse Tme locusCell, 1992
- Genomic imprinting in mammalian development: a parental tug-of-warTrends in Genetics, 1991
- The gene structure of the insulin-like growth factor familyProgress in Growth Factor Research, 1989
- Spatial and temporal pattern of cellular myc oncogene expression in developing human placenta: Implications for embryonic cell proliferationCell, 1984