Tumor Suppressor Genes: Does FHIT Fit?
Open Access
- 18 March 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 90 (6) , 412-414
- https://doi.org/10.1093/jnci/90.6.412
Abstract
What is a tumor suppressor gene? From a functional point of view, it is a gene whose product can restrict the tumorigenic and metastatic processes at a certain step. From a genetic point of view, both alleles of a tumor suppressor gene are inactivated directly through deletion, inactivating mutations, or epigenetic modifications (e.g., methylation) in neoplastic cells but not in their normal counterparts.Keywords
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