CYTOCHROME P‐450‐DEPENDENT O‐DEALKYLASE ACTIVITY IN MAMMALIAN SKIN
Open Access
- 1 January 1982
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 75 (1) , 123-127
- https://doi.org/10.1111/j.1476-5381.1982.tb08764.x
Abstract
A modified technique for the measurement of O‐dealkylase (ODA) activity in crude homogenates is reported, and its application to skin is described. Large differences in ODA levels were found between different species, no activity being observed in the skin of primates. Induction of cutaneous ODA in mice was achieved by the subcutaneous injection of phenobarbitone, hexachlorobenzene or 20‐methylcholanthrene. Attempts to induce ODA in vitro were unsuccessful.Keywords
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