Reductive Generation of Enolates from Enones Using Elemental Hydrogen: Catalytic C−C Bond Formation under Hydrogenative Conditions
- 28 November 2002
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (51) , 15156-15157
- https://doi.org/10.1021/ja021163l
Abstract
Exposure of enones to elemental hydrogen in the presence of a Rh(I) catalyst enables reductive enolate generation, as evidenced by electrophilic trapping of the enolate by appendant and exogenous aldehyde partners. The significance of these findings resides in the ability to regioselectivity generate and transform transition metal enolates under catalytic conditions that circumvent formation of stoichiometric byproducts.Keywords
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