Intracanalicular Collagen Implants Enhance Topical Antibiotic Bioavailability

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Abstract
Canalicular occlusion is a simple method to increase topical ocular antibiotic drug bioavailability and efficacy. Absorbable intracanalicular collagen implants were placed in the lacrimal drainage system of New Zealand white rabbits before instillation of one 50-μl drop of 0.3% tobramycin. Using a bacteriologic bioassay, tobramycin tear and corneal concentrations were greater in occluded animals as compared to those not occluded up to 2 h after antibiotic administration (p

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