Urinary prostanoids in postmenopausal women after transdermal and oral oestrogen

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Abstract
The urinary metabolites of prostacyclin and of its counterpart, thromboxane, were determined in 40 postmenopausal women who had been treated with transdermal or oral oestrogen for 4 weeks. With oestradiol valerate administered by mouth there was an increase in prostacyclin metabolites. A decrease in thromboxane metabolites was observed only with transdermal oestradiol. Thus, both oral and transdermal oestrogen had positive effects on the prostacyclin thromboxane ratio. This may be one of the biochemical actions by which oestrogen has a beneficial effect on the cardiovascular system in postmenopausal women.