Cerebrospinal fluid ß 2 microglobulin in patients infected with human immunodeficiency virus
- 1 June 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (6) , 830
- https://doi.org/10.1212/wnl.39.6.830
Abstract
We prospectively evaluated CSF concentrations of ß2 microglobulin (ß2M) in 65 human immunodeficiency virus type 1 seropositive patients. The highest concentrations occurred in those with lymphoma, neurologic opportunistic infections, and acquired immune deficiency syndrome dementia complex (ADC). There was a high correlation between the CSF ß2M concentration and ADC severity, suggesting that CSF ß2M may be useful as a marker for the development, progression, and perhaps response to treatment of ADC. Elevated CSF ß2M was not due to CSF pleocytosis and was usually independent of blood-brain barrier dysfunction.This publication has 9 references indexed in Scilit:
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