Uncoupler-and hypoxia-induced damage in the working rat heart and its treatment
- 1 March 1985
- journal article
- research article
- Published by Springer Nature in Basic Research in Cardiology
- Vol. 80 (2) , 107-115
- https://doi.org/10.1007/bf01910457
Abstract
In the isolated working rat heart, the damaging effect of 0.05–0.06 μM Carbonylcyanide-p-trifluoro-methoxyphenylhydrazone (FCCP) was reversible within 20 sec by perfusion with fresh buffer. Cysteine 3 mM restored the aortic flow to the initial value within an additional 15–20 sec. Thereafter, the FCCP effect became irreversible due to a progressive structural membrane change. The structural change by FCCP is probably brought about by ‘internalization’ of polar groups (R-SH; R−NH3 +) of the mitochondrial (and other) membrane.Keywords
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