Pidotimod Stimulates Natural Killer Cell Activity and Inhibits Thymocyte Cell Death
- 1 January 1992
- journal article
- Published by Taylor & Francis in Immunopharmacology and Immunotoxicology
- Vol. 14 (4) , 737-748
- https://doi.org/10.3109/08923979209009231
Abstract
Experiments were performed to analyze the possible effect of the immunomodulating agent Pidotimod (3-L-pyroglutamyl-L-thiazolidine-4-carboxylic acid) on mouse Natural Killer (NK) cell activity and glucocorticoid hormone(GCH)-induced thymocyte apoptosis. The results indicate that in vivo treatment with Pidotimod (200 mg/Kg ip for 5 days) causes a significant increase in NK activity and in vitro treatment produces a significant reduction of dexamethasone-induced thymocyte apoptosis. This inhibition appears to be dose-dependent and is also evident against TPA or Ca++ionophore-induced apoptosis.Keywords
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