Absolute Asymmetric Synthesis: The Origin, Control, and Amplification of Chirality
- 7 December 1999
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 38 (23) , 3418-3438
- https://doi.org/10.1002/(sici)1521-3773(19991203)38:23<3418::aid-anie3418>3.0.co;2-v
Abstract
Biomolecular homochirality, the origin of which is still a puzzle, has challenged scientists to design chemical systems that provide chiral molecules through absolute asymmetric synthesis and to amplify a small stereochemical bias in such systems. The photoresolution of the enantiomers of helical-shaped, sterically overcrowded alkene 1 with circularly polarized light and the transduction of the stereochemical information by triggering the helical arrangement of a large collection of achiral molecules in a twisted nematic liquid crystalline phase (2) are examples of control and amplification of chirality.This publication has 0 references indexed in Scilit: