Some pharmacokinetic data about furaltadone and nitrofurazone administered orally to preruminant calves
Open Access
- 1 July 1987
- journal article
- research article
- Published by Taylor & Francis in Veterinary Quarterly
- Vol. 9 (3) , 208-214
- https://doi.org/10.1080/01652176.1987.9694102
Abstract
A single oral dosage of furaltadone and nitrofurazone (14.0 mg/kg) to 5 preruminant calves (in a cross‐over trial) revealed mean maximum plasma concentration of 2.5 and 3.5 pg/ml, respectively, at approximately 3 h after administration. The final elimination half‐lives of furaltadone and nitrofurazone were 2.5 and 5 h, respectively. Urinary recovery of these two nitrofurans in 3 calves revealed approximately 2% of the orally administered dose. The renal clearance of the unbound drugs did not differ (for both drugs approximately 0.42 ml/min/kg);furaltadone clearance was strongly related to urine flow.This publication has 8 references indexed in Scilit:
- Kinetics of14C‐furazolidone in piglets upon oral administration during 10 days and its interaction with tissue macro‐moleculesFood Additives & Contaminants: Part A, 1986
- Dose dependent disposition of sulphadimidine and of its N4‐acetyl and hydroxy metabolites in plasma and milk of dairy cowsVeterinary Quarterly, 1985
- Mutagenicity of nitrofuran derivatives: ReviewEnvironmental Mutagenesis, 1983
- Determination of nitrofurantoin (Furadantine®) and hydroxymethylnitro-furantoin (Urfadyn®) in plasma and urine of man by means of high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1979
- Binding of nitrofuran derivatives to nucleic acids and protein.CHEMICAL & PHARMACEUTICAL BULLETIN, 1977
- Metabolism of Furazolidone in SwineExperimental Biology and Medicine, 1971
- Metabolic Degradation of the NitrofuransJournal of Medicinal Chemistry, 1960