Selection of Carcinogens and Related Compounds Tested for Mutagenic Activity

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Abstract
A list of 102 chemical was prepared for subsequent mutagenesis assay in National Cancer Institute program to determine the extent of correllation between carcinogenesis and mutegenesis in standardized assays. The chemical were divided into five major categories: 37 aromatic amines, 11 polycyclic aromatic hydrocarbons, 8 nitrosamines and nitrosamides, 16 alkylating agents, and a miscellaneous category consisting of 11 heterocyclic compounds, 7 amides, ureas and acylating agents, 5 antimetabolites, 4 inorganic chemicals, and 3 promoters. The chemicals were further described as procarcinogens (requiring metabolic activation to exert their biologic activities), ultimate carcinogens (direct-acting chemicals not requiring metabolic activation), and noncarcinogens (compound shown to be Inactive in one or more adequate carcinogenicity tests). An extensive bibliography documents the selection and categorization of the compounds.