Electro‐oculographic findings in Machado‐Joseph disease
- 1 November 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 32 (11) , 1272
- https://doi.org/10.1212/wnl.32.11.1272
Abstract
Electro-oculographic recordings (EOG) were made on 26 patients with Machado-Joseph disease or at genetic risk for that disease. All patients with clinically apparent disease (ataxia, dysarthria, spasticity, or ophthalmoparesis) had abnormal eye movements. Defects in caloric response, sinsuoidal tracking, opticokinetic nystagmus (OKN), refixation saccades, and presence of gaze paretic nystagmus were detected in that order of frequency. Fourteen subjects were clinically at risk but had normal neurologic examinations or minor equivocal signs. Nine of the fourteen had abnormal EOG, with sinusoidal tracking, calorics, refixation saccades, OKN, and gaze paretic nystagmus being abnormal in that order. EOG may be useful in early case detection and may contribute to genetic counseling.This publication has 3 references indexed in Scilit:
- Autosomal dominant system degeneration in Portuguese families of the Azores IslandsNeurology, 1978
- Azorean Disease of the Nervous SystemNew England Journal of Medicine, 1977
- Slow Eye Movements, With Absent Saccades, in a Patient With Hereditary AtaxiaArchives of Neurology, 1977