An Efficient Stereoselective Preparation of Vitamin E (α-Tocopherol) from Phytol
- 1 January 1990
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1990 (08) , 451-452
- https://doi.org/10.1055/s-1990-21990
Abstract
Vitamin E (α-tocopherol) (5) has been prepared efficiently from phytol (7). The key step is the treatment of (2S,3R,7R, 11R)-1-chloro-2,3-epoxy-3,7,11,15-tetramethylhexadecane, derived from phytol by sequential Sharpless epoxidation and chlorination, with butyllithium to give (3R,7R,11R)- 3,7, 11,15-tetramethyl-1-hexadecyn-3-ol (6).Keywords
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