Urinary acid mucopolysaccharides in Multiple Sulfatase Deficiency (Mucosulfatidosis)
- 1 November 1979
- journal article
- research article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 132 (3) , 207-211
- https://doi.org/10.1007/bf00442437
Abstract
Urinary acid mucopolysaccharide (AMPS) excretion was investigated in a Japanese case with Multiple Sulfatase Deficiency (MSD) (Mucosulfatidosis). The patient excreted AMPS 4 to 5 times more (as carbazoluronic acid) than controls. The cellulose acetate gel electrophoresis clearly indicated two major AMPS which co-migrated with heparan sulfate and chondroitin sulfate A/C. Enzymic digestion with chondroitinase AC and ABC, and by testicular hyaluronidase plus amino sugar analysis also confirmed that our case excreted heparan sulfate and chondroitin sulfate A/C. These findings suggest that there are heterogeneities of urinary AMPS excretion among cases with MSD.This publication has 15 references indexed in Scilit:
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