A General Method for the Preparation of β-Aminoesters
- 1 January 1989
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1989 (10) , 747-751
- https://doi.org/10.1055/s-1989-27381
Abstract
3-Dialkylamino (3) and 3-benzyloxycarbonylamino (6) esters are prepared by the Reformatsky reaction of 1-dialkylamino-(1) and 1-benzyloxycarbonylamino-(5) 1-(1-benzotriazolyl)alkanes with ethyl 2-bromoalkanoates. Compounds 1 and 5 are obtained by the condensation of benzotriazole, an aldehyde, and a secondary amine or benzyl carbamate. The procedure can be performed by as a one-pot reaction from benzotriazole.Keywords
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