PORCINE MALIGNANT HYPERTHERMIA. VIII: LEG METABOLISM

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Abstract
Leg metabolisM.During porcine malignant hyperthennia (MH) was investigated in eight Pietrain pigs. There was an efflux of glucose, lactate, pynivale and alanine from the leg during MH, demonstrating the occurrence of rapid glycogen degradation. Potassium production by the leg did not change significantly and the decrease in free fatty acid efflux together with the maintenance of grycerol production suggested the utilization of intramuscular triglycerides. The failure of leg blood flow to increase during MH limited the oxygen consumption of the muscle as maximal oxygen extraction occurred early in the response. In a further six Pietrain pigs it was shown that the infusion of sodium nitroprusside increased leg blood flow only slightly. It is possible that the inability of leg blood flow to increase in MH was a result of the decline in cardiac output

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