Expression of Tac antigen on activated normal human B cells.
Open Access
- 1 August 1984
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 160 (2) , 612-617
- https://doi.org/10.1084/jem.160.2.612
Abstract
Two-color fluorescence analysis revealed that Tac antigen, which was previously reported to be restricted to T cells, was expressed on a proportion of normal B cells activated by Staphylococcus aureus Cowan I (SAC). Immunoaffinity-purified interleukin 2 (IL-2) induced the proliferation of SAC-activated B cells, and the proliferation was completely inhibited by anti-Tac antibody, which blocked the membrane binding and action of IL-2. These results suggest that an IL-2 receptor system is directly involved in the B cell immune response.Keywords
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