Risk assessment in cancer patients with fever and neutropenia: a prospective, two-center validation of a prediction rule.
- 1 February 1992
- journal article
- abstracts
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 10 (2) , 316-322
- https://doi.org/10.1200/jco.1992.10.2.316
Abstract
PURPOSEThe study was undertaken to validate a clinical model for predicting the medical risk of cancer patients with fever and neutropenia.PATIENTS AND METHODSA consecutive sample of 444 cancer patients with fever and neutropenia (granulocyte count less than 500/microL) at two hospitals, a specialized cancer referral center and a university-affiliated general medical hospital, was studied to identify clinical characteristics in the first 24 hours that predict subsequent serious medical complications during the hospital stay. To control for bias, major risk factors and complications were subject to blinded review.RESULTSSerious medical complications occurred in 34% of patients with risk factors identified in a prior study, including prior inpatient status (group I), outpatients with a serious independent comorbidity (group II), or uncontrolled cancer (group III), compared with 5% of the remaining patients (group IV) (P less than .000001). Two of the complications in group IV patients were transient asympto...Keywords
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