DISENECIOYL DEHYDRORETRONECINE SYNTHESIS AND ACUTE HEPATIC TOXICITY OF A PYRROLIZIDINE ALKALOID PYRROLE ANALOG

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (1) , 53-73
Abstract
Disenecioyl dehydroretronecine (DSDR), a semi-synthetic analogue of the highly reactive pyrrole metabolites of the pyrrolizidine alkaloids, was synthesized from disenecioyl retronecine. Rats which received 40 mg DSDR/kg body weight via the mesenteric vein showed multiple depressed areas (< 2 mm in diameter) on the surface of the median lobe of the liver. Microscopically these areas consisted of hepatic venous occlusion, necrosis and proliferation of fibroblasts and bile ducts in and around the portal triad. These hepatic lesions were similar to those produced by dehydroretrorcine.

This publication has 1 reference indexed in Scilit: