The cellular basis of the impaired autologous mixed lymphocyte reaction in patients with systemic lupus erythematosus.
- 1 January 1979
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 63 (1) , 151-153
- https://doi.org/10.1172/JCI109270
Abstract
The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease.This publication has 10 references indexed in Scilit:
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