MYOCARDIAL EFFECTS OF MITOXANTRONE AND DOXORUBICIN IN THE MOUSE AND GUINEA-PIG

  • 1 January 1984
    • journal article
    • research article
    • Vol. 68  (6) , 841-847
Abstract
Mitoxantrone (DHAQ) was compared to doxorubicin [both antineoplastic drugs] for myocardial effects in the mouse and the guinea pig. Histologically, DHAQ induced a high incidence of focal myocardial damage in mice, similar to that observed with doxorubicin. Functionally, like doxorubicin, DHAQ significantly reduced the rate of contraction and histamine responsiveness of guinea pig right atria in vitro. Additionally, long-term i.p. administration of DHAQ or doxorubicin reduced the atrial response to histamine in vitro. DHAQ may have a spectrum of myocardial activity similar to that of doxorubicin.

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